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Omega-3 vs Omega-6 Fatty Acids



There is a ton of evidence (see resources below, for a few samples) that discusses the relationship between Omega-3 (ω-3) and Omega-6 (ω-6) fatty acids, especially when it comes to achieving a healthy ratio of the two. A healthy ratio would be 3:1 ω-3 to ω-6, however, the current American diet is estimated to be closer to 1:16. Inflammation is thought to be one primary method for the development of damage to the inside of arteries leading to increased risk of heart attack and stroke.

ω-6: Polyunsaturated type of fatty acid, contains a double bond at the #6 carbon (and more at every 3rd carbon after)
  • Double bonds are more susceptible to oxidation, making them more volatile and able to interact with other fats nearby, leading to cell damage/death
  • Are Pro-inflammatory (by way of the formation into Arachidonic Acid (AA), then thromboxanes, prostaglandins, and leukotrienes)
  • Typical food sources are corn, soy, and their processed oils

Omega-3 fatty acids work in opposition to Omega-6 fatty acids in the body by acting as an Anti-inflammatory agent, reducing the inflammation in the body and preventing damage to arteries. Foods high in Omega-3's include:
  • Walnuts, flaxseed, chia seeds, and their processed oils
  • Cold-water fish such as salmon (see above), sardines, anchovies, herring, albacore tuna, and mackerel
  • green leafy vegetables like spinach and brussels sprouts, as well as cauliflower, a variety of winter squashes herbs like purslane
  • any type of animal meat or byproduct with high dietary intake of the above foods: for example grass-fed livestock and wild game have the higher Omega-3 content in their meats and eggs (hence why wild salmon, who eat more Omega-3-rich algae, have higher Omega-3 content than corn-fed farmed salmon, which are higher in Omega-6)
It turns out you really are what you eat; at least animals are.


Resources
  1. Hodson L, Eyles HC, McLachlan KJ, Bell ML, Green TJ, and Skeaff CM. Plasma and erythrocyte fatty acids reflect intakes of saturated and n-6 PUFA within a similar time frame. J Nutr. 2014; 144:33-41.
  2. Bazinet RP and Layé S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014; 15:771-785. 
  3. Patterson E, Wall R, Fitzgerald GF, Ross RP, and Stanton C. Health implications of high omega-6 polyunsaturated fatty acids. J Nutr Metab. 2012; 2012:539426. Doi: 10.1155/2012/539426.
  4. Simopoulos AP. The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002 Oct; 56(8):365-379.

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